- 作者: Susan J. Marriott a,b, Francene J. Lemoine b, Kuan-Teh Jeang c
- 作者服務機構: a Department of Molecular Virology and Microbiology, b Program in Cell and Molecular Biology, Bavlor College of Medicine, Houston, Tex., c Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Md., USA
- 中文摘要: --
- 英文摘要: Genetic instability is a recurring theme in human can-cers. Although the molecular mechanisms mediatingthis effect commonly observed in transformed cells arenot completely understood, it has been proposed toinvolve either the loss of DNA repair capabilities or theloss of chromosomal stability. The transforming retrovi-rus human T cell leukemia virus type I (HTLV-I) encodes aviral oncoprotein Tax, which is believed to cause thegenomic instability characteristic of HTLV-I-infectedcells. This review focuses on the ability of HTLV-I Tax todisrupt the cellular processes of DNA repair and chromo-somal segregation. The consequences of these effects aswell as the evolutionary advantage this may provide toHTLV-l are discussed.
- 中文關鍵字: --
- 英文關鍵字: HTLV-I, Tax, Transformation, Genome stability