- 作者: Jo M. Lewohl PeterR. Dodd R. Dayne Mayfield R. Adron harris
- 作者服務機構: Waggoner Center for Alcohol and addiction Research, University of Texas at Ausin, Tex., USA; Department of Biochemistry, University of Queensland, St Lucia, Australia
- 中文摘要: --
- 英文摘要: An emerging idea is that long-term alcohol abuse resultsin changes in gene expression in the brain and that thesechanges are responsible at least partly for alcohol toler-ance, dependence and neurotoxicity. The overall goal ofour research is to identify genes which are differentiallyexpressed in the brains of well-characterized humanalcoholics as compared with non-alcoholics. This shouldidentify as-yet-unknown alcohol-responsive genes, andmay well confirm changes in the expression of geneswhich have been delineated in animal models of alcoholabuse. Cases were carefully selected and samplespooled on the basis of relevant criteria; differential ex-pression was monitored by microarray hybridization.The inherent diversity of human alcoholics can be ex-ploited to identify genes associated with specific patho-logical processes, as well as to assess the effects of con-comitant disease, severity of brain damage, drinkingbehavior, and factors such as gender and smoking histo-ry. Initial results show selective changes in gene expres-sion in alcoholics; of particular importance is a coordi-nated reduction in genes coding for myelin compo-nents.
- 中文關鍵字: --
- 英文關鍵字: Gene expression. Gene chip. Myelin. Frontal cortex