- 作者: Younyoung Kim; Chaeyoung Lee
- 作者服務機構: Ilsong Institute of Life Science, Hallym University, South Korea
- 中文摘要: --
- 英文摘要: Osteopontin (OPN) is a cytokine that involvesin vascular remodeling processes in cerebrovasculardiseases. The association of its gene with ischemic strokewas investigated in a Korean population. Representativesequence variants covering the entire OPN gene weregenotyped in 455 controls and 271 patients with ischemicstroke including large artery atherosclerosis (LAA), smallvessel occlusion, and cardioembolism. Analysis with theindividual tagging variants and their haplotypes revealed anevidence of association only with LAA. Significances wereshown with the haplotypes, especially with the TCA at theloci C2140T, C5891T, and A7385G conferring a risk of2.09 for LAA (P\0.05). The CG at the loci C1013T andA7385G was the most protective haplotype (OR = 0.66,P\0.05). Our findings suggested that several haplotypesof OPN gene contributed to determining risk factors as wellas protective factors of LAA.
- 中文關鍵字: --
- 英文關鍵字: Genetic polymorphism; Ischemic stroke; Risk factor