- 作者: Synthesis of Some New Spiro, Isolated and Fused Heterocycles Based on 1H-indole-2-one
- 作者服務機構: Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt
- 中文摘要:
The reaction of 3-benzoylcyanomethylidine-1(H)-indole-2-one (1) with a variety of active methylene compounds, thioglycolic acid, glycine, hydrazine hydrate and phenyl hydrazine led to the formation of compounds 4a-d-10. 3-Thiosemicarbazide-1(H)-indole-2-one 2 on reaction with a-halocarbonyl compounds gave compounds 11a-c, 12a-c. The latter compounds on heating with phosphoryl chloride, cyclization takes place via losing water to give the angular tetracyclic compounds 13a,b and 14a-c. Cyanoacetic hydrazone derivative 3 readily cyclized upon heating in triethyl orthoformate to give the tricyclic system, oxopyridazino indole 15.
On the other hand, the reaction of 3 with benzylidine malononitrile and benzylidene ethylcyanoactate gave the pyranyl hydrazone derivatives 16a,b. - 英文摘要: --
- 中文關鍵字: --
- 英文關鍵字: --