- 作者: Shuangling Chen, Qin Zhu, Hong Sun, Yuan Zhang, Sean Tighe, Li Xu and Yingting Zhu
- 作者服務機構: 1.Tissue Tech, Inc., 7235 Corporate Center Drive, Suite B, Miami, Florida 33126, USA 2.Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University (the Second People’s Hospital of Yunnan Province), Key Laboratory of Yunnan Province for the Prevention and Treatment of Ophthalmology, Provincial Innovation Team for Cataract and Ocular Fundus Disease, The Second People’s Hospital of Yunnan Province, Expert Workstation of Yao Ke, Yunnan Eye Institute, Kunming, 650021, China 3.Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China 4.The Department of Ophthalmology, The Affiliated Hospital of Inner Mongolia Medical University, Tongdao North Rd, Hohhot, Inner Mongolia, China
- 中文摘要:
- 英文摘要:
Human corneal endothelial cells are notorious for their restricted proliferative ability in vivo and in vitro. Hence, injury or dysfunction of these cells may easily result in blindness. Currently, the only treatment is to transplant a donor cornea that contains a healthy corneal endothelium. However there is a severe global shortage of donor corneas and there remains an unmet clinical need to engineer human corneal grafts with healthy corneal endothelium. In this review, we present current advances in the culture, expansion, and molecular understandings of corneal endothelial cells in vitro in order to help establish methods of engineering human corneal endothelial grafts. - 中文關鍵字:
- 英文關鍵字: Cornea, Endothelium, Expansion, Mechanism