- 作者: 方俊民
- 作者服務機構: Department of Chemistry, National Taiwan University, Taipei 106, Taiwan, R.O.C.
- 中文摘要: Alkyl-, phenyl- and alkynyllithium reagents in combination with anhydrous cerium(III) chloride underwent addition reactions with 1,3-dichloroacetone in a very efficient manner. The addition products are versatile precursors for 2-substituted epichlorohydrins and glycidols. Fluconazole, a potent antifungal agent, was thus synthesized in 67% yield by addition of 1,3-dichloroacetone to 2,4-difluorophenyllithium in the presence of cerium(III) chloride, followed by substitution of the chlorine atoms with 1,2,4-triazole.
- 英文摘要: --
- 中文關鍵字: 1,3-Dichloroacetone; Organolithium reagents; Cerium(III) chloride; Fluconazole; Epichlorohydrins; Glycidols.
- 英文關鍵字: --