- 作者: 王躬仁; 陳豪勇; 陳健和; 葉明陽; 三上襄
- 作者服務機構: 臺北醫學院醫學系; 行政院衛上署預防醫學研究所; 國防醫學院微免系; 日本千葉大學
- 中文摘要: 老鼠以熱殺死的酪酸菌處理後,在DDY品系老鼠具有抗sarcoma 180的效果,而在BDF1品系老鼠則具有抑制黑色素瘤轉移的效果。酪酸菌在體外無法抑制這些癌細胞的增殖,因此可能與免疫增強有關。經本實驗分析結果發現,酪酸菌死菌在老鼠體內可促進抗體的產生、干擾素的分泌、增強巨噬細胞及NK細胞之殺細胞功能,因此酪酸菌在老鼠體內具抑癌增強效果,可能與老鼠的免疫系統被活化有關。
- 英文摘要: Bacterial vaccine, as generated by heat-inactivated Clostridium butyricum cells, displayed antitumoractivity against sarcoma 180 in DDY mice and antimetastatic activity against B16-F10 melanoma in BDF1mice. According to our results, the vaccine has no direct growth inhibitory effect toward the tumor cell linestested in this study. The vaccine increased gamma-interferon production, elicited delayed type hypersensitiv-ity reaction, and enhanced IgM antibody formation and mitogenicity. The phagocytic activity of macrophageand killing activity of NK cells from mice were enhanced in a dose-dependent manner by stimulating with theheat-inactivated vaccine. Among those responses in the mice treated with CB, elevated NK cell activity mayplay a prominent role in manifesting antitumor activity in the B16-F10 metastasis experiment.
- 中文關鍵字: Clostridium butyricum; vaccine; antitumor activity; immunpotentiating activity.
- 英文關鍵字: --