- 作者: 許如婷,張彥誠,張夢揚
- 作者服務機構: Department of Applied Chemistry, National University of Kaohsiung, Kaohsiung City 811, Taiwan, R.O.C.
- 中文摘要: Base-induced coupling/cyclization stepwise [3+2] annulation of a-sulfonylacetamide with (Z)-2-bromoacrylates yielded polysubstituted pyroglutamates with three contiguous chiral centers with trans-trans orientation in a one-pot synthesis. The pyrrolizidine skeleton was obtained via an intramolecular cyclization. This facile strategy was used to synthesize (±)-trachelanthamidine.
- 英文摘要: --
- 中文關鍵字: Trachelanthamidine; Pyrrolizidine alkaloids; Polysubstituted pyroglutamates; Intermolecular formal [3+2] annulation; Intramolecular cyclization.
- 英文關鍵字: --