- 作者: Chin-Hung Liu; Jin-ding Huang; Shi-Wei Huang; Tzyh-Chyuan Hour; Yung-Kai Huang; Yu-Mei Hsueh; Hung-Yi Chiou; Te-Chang Lee; Kun-Yan Jan; Chien-Jen Chen; Yeong-Shiau Pu
- 作者服務機構: 1 Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; ; 2 Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan; ; 3 Department of Urology, National Taiwan University College of Medicine and Hospital, 7 Chung-Shan South Road, Taipei, 100, Taiwan; ; 4 Institute of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan; ; 5 Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan; ; 6 School of Public Health, Taipei Medical University, Taipei, Taiwan; ; 7 Institute of Biomedical Sciences Academia S璯ica, Taipei, Taiwan; ; 8 Institute of Zoology, Academia S璯ica, Taipei, Taiwan; ; 9 Genomic Research Center, Academia S璯ica, Taipei, Taiwan
- 中文摘要: --
- 英文摘要: The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (< 22) repeats, had an elevated risk than those with longer CAG and GGN (OR 4.32 and 4.57, p = 0.034 and 0.042, respectively). However, neither CAG nor GGN affected the UC risk in non-smokers or heavy smokers (≧25 packs per day-years). AR CAG polymorphism may affect the risk of UC in both genders. In addition, AR polymorphisms may influence carcinogenic effect of medium-dose of cigarette smoking in men.
- 中文關鍵字: --
- 英文關鍵字: bladder neoplasms, urinary tract, tobacco, trinucleotide repeats, carcinogenesis