- 作者: Kuan-Teh Jeang
- 作者服務機構: Molecular Virology Section, Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda, Md., USA
- 中文摘要: --
- 英文摘要: The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phos-phorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcription. We discuss evidence that suggests involvement of TFIIH and/or P-TEFb.
- 中文關鍵字: --
- 英文關鍵字: Human immunodeficiency virus ; Tat; Transcription ; Sp1; RNA polymerase II ; Protein kinase