- 作者: Kuei-Hsiang Pan, Hung Chang & Wei Yuan Yang
- 作者服務機構: 1.Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei, Taiwan 2.Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
- 中文摘要:
- 英文摘要:
Mammalian cells release a wealth of materials to their surroundings. Emerging data suggest these materials can even be mitochondria with perturbed morphology and aberrant function. These dysfunctional mitochondria are removed by migrating cells through membrane shedding. Neuronal cells, cardiomyocytes, and adipocytes send dysfunctional mitochondria into the extracellular space for nearby cells to degrade. Various studies also indicate that there is an interplay between intracellular mitochondrial degradation pathways and mitochondrial release in handling dysfunctional mitochondria. These observations, in aggregate, suggest that extracellular release plays a role in quality-controlling mammalian mitochondria. Future studies will help delineate the various types of molecular machinery mammalian cells use to release dysfunctional mitochondria. Through the studies, we will better understand how mammalian cells choose between intracellular degradation and extracellular release for the quality control of mitochondria. - 中文關鍵字:
- 英文關鍵字: Extracellular vesicles, Mitochondria, Organelle quality control, Autophagy, Mitophagy