- 作者: Phillip E. Posch; Francisco Borrego; Andrew G. Brooks; John E. Coligan
- 作者服務機構: a Structural Biology Section, and ; b Laboratory of Immunogenetics, National Institute of Allergy and Infectious Disease, National Institutes of Health, Twinbrook II, Rockville, Md, USA
- 中文摘要: --
- 英文摘要: CD94/NKG2 is a recently described receptor present on natural killer (NK) cells and certain T cells that is composed of the CD94 chain covalently associated with a member of the NKG2 family of molecules. Both chains are glycosylated members of the C-type lectin superfamily. The CD94/NKG2 receptors are functionally heterogenous depending on which NKG2 family member is associated with CD94. Initially, it was thought that CD94/NKG2 receptors recognized a broad array of HLA-A, -B and -C (classical), as well as the non-classical HLA-G, MHC class I molecules. Instead, recent data have suggested that this receptor is specific for HLA-E complexed with a peptide derived from the signal sequence (residues 3-11) of certain classical MHC class I molecules. Position 2 (residue 4) in the signal sequence derived peptides appears pivotal in determining whether the HLA-E/peptide complex confers resistance to NK-mediated lysis. The potential roles that the CD94/NKG2-HLA-E receptor ligand interaction might play in infection and tumor development are discussed.
- 中文關鍵字: --
- 英文關鍵字: Natural killer cells; HLA-E; CD94; NKG2; Major histocompatibility complex, class I