- 作者: Bing Sun Jun-ichi Kambayashi
- 作者服務機構: Vasular Biology, Maryland Research Laboratories, Otsuka America Pharmacutical, Inc., Rockville, Md., USA
- 中文摘要: --
- 英文摘要: Ca influx is an important event associated with plateletactivation and regulated by the content of intracellularCa . Previous studies have suggested two different Ca pools and two Ca influx pathways exist in platelets. Inthe present study, we have investigated the regulation ofthrombin- and thapsigargin-induced Ca entry into hu-man platelets, using fluorescent indicators to monitorCa mobilization and membrane potential. It was foundthat depletion of thapsigargin-sensitive Ca stores wascoupled to Ca influx through a Cat-selective pathway.Additional release of Ca from the thapsigargin-insensi-tive pool by thrombin caused the opening of a nonselec-tive cation channel.
- 中文關鍵字: --
- 英文關鍵字: --