• 作者： Bing Sun Jun-ichi Kambayashi
• 作者服務機構： Vasular Biology, Maryland Research Laboratories, Otsuka America Pharmacutical, Inc., Rockville, Md., USA
• 中文摘要： --
• 英文摘要： Ca influx is an important event associated with plateletactivation and regulated by the content of intracellularCa . Previous studies have suggested two different Ca pools and two Ca influx pathways exist in platelets. Inthe present study, we have investigated the regulation ofthrombin- and thapsigargin-induced Ca entry into hu-man platelets, using fluorescent indicators to monitorCa mobilization and membrane potential. It was foundthat depletion of thapsigargin-sensitive Ca stores wascoupled to Ca influx through a Cat-selective pathway.Additional release of Ca from the thapsigargin-insensi-tive pool by thrombin caused the opening of a nonselec-tive cation channel.
• 中文關鍵字： --
• 英文關鍵字： --