- 作者: Sharona Vonck, Anneleen S. Staelens, Dorien Lanssens, Kathleen Tomsin, Jolien Oben, Liesbeth Bruckers and Wilfried Gyselaers
- 作者服務機構: 1. Faculty of Medicine and Life Sciences, Hasselt University, Agoralaan, 3590 Diepenbeek, Belgium 2. Department of Obstetrics & Gynaecology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, 3600 Genk, Belgium 3. Interuniversity Institute for Biostatistics and statistical Bioinformatics, Hasselt University, Agoralaan, 3590 Diepenbeek, Belgium 4. Department Physiology, Hasselt University, Agoralaan, 3590 Diepenbeek, Belgium
- 中文摘要:
- 英文摘要:
Background
To investigate the possibility of using maternal biophysical parameters only in screening for the different types of gestational hypertensive diseases.
Methods
A total of 969 pregnant women were randomly screened in first and second trimester, of which 8 developed Early-onset Preeclampsia, 29 Late-onset Preeclampsia, 35 Gestational Hypertension and 897 women had a normal outcome. An observational maternal hemodynamics assessment was done via standardized electrocardiogram-Doppler ultrasonography, Impedance Cardiography and bio-impedance, acquiring functional information on heart, arteries, veins and body fluid. Preliminary prediction models were developed to test the screening potential for early preeclampsia, late preeclampsia and gestational hypertension using a Partial Least Square Discriminant Analysis.
Results
A combined model using maternal characteristics with cardiovascular parameters in first and second trimester offers high screening performance with Area Under the Curve of 99,9% for Early-onset Preeclampsia, 95,3% for Late-onset Preeclampsia and 94% for Gestational Hypertension.
Conclusions
Using biophysical parameters as fundament for a new prediction model, without the need of biochemical parameters, seems feasible. However, validation in a large prospective study will reveal its true potential. - 中文關鍵字:
- 英文關鍵字: Gestational hypertensive diseases, Hypertension, Preeclampsia, Screening, Biophysical parameters, Prediction