• 作者： 歐陽培銓; 周松男; 黃思誠; 謝長堯
• 作者服務機構： 國立臺灣大學醫學院附設醫院婦產科
• 中文摘要： 本研究包括30位停經中國婦女，其中14位為自然停經，13位為去勢停經婦女，及3個放射線療法後停經婦女。他們每天口服1.25 mg的Premarin，連續3星期，停藥1星期，重覆6個週期。 禁食的晨尿和血液標本採集的時間為荷爾蒙治療前，及Premarin治療3週，11週及23週後。 血清總動情激素用放射免疫分析來測量，尿液中的鈣和肌酸酐分別用原子吸收及Jeffe反應來測量。尿液中Hydroxy-proline的濃度用Kivirikko方法來測量。 在Premarin 治療後，血清總動情激素平均濃度比治療前的濃度（71.1 pg/ml）增加3至4倍。另一方面，鈣／肌酸酐（Ca/Cr）莫耳比從0.249降至0.098。Hydroxyproline∕肌酸酐（HOPr/Cr）莫耳比從0.028降至0.012。 鑑於Premarin治療後的荷爾蒙及生化變化，動情激素（Premarin）替代療法對於治療停經婦女的亢進骨質脫失或骨質疏鬆應該是有效的。文中也討論動情激素與Calcitonin在調節骨代謝方面的關係。
• 英文摘要： The study subjects included a total of 30 postmenopausal Chinese women, including 14 naturalmenopausal women, 13 castrated menopausal women and 3 post-irradiated menopausal women. Premarin1.25 mg/day was given orally for 3 weeks and off one week, repeated for 6 cycles. Fasting morning urine and blood samples were collected before hormone treatment and at the endof 3 weeks, 11 weeks, and 23 weeks of Premarin therapy. Serum total estrogen level was measured by radioimmunoassay. Urinary calcium and creatinine weremeasured by atomic absorption and Jeffe's reaction, respectively. The concentration of urinary hydroxy-proline was determined by Kivirikko's method. After Premarin therapy, the mean concentration of serum total estrogen increased 3 to 4 times fromthe pretreatment level of 71.7 pg/ml. On the other hand, the mean value of calcium/creatinine (Ca/Cr)molar ratio dropped down from 0.249 to 0.098. The mean value of hydroxyproline/creatinine (HOPr/Cr)molar ratio was reduced from 0.028 to 0.012. In view of the hormonal and biochemical changes after Premarin tharapy, it is concluded that estro-gen (Premarin) replacement should be effective in the treatment of enhanced bone loss or osteoporosis inpostmenopausal women. The relationship of estrogen and calcitonin in the regulation of bone metabolismis also discussed.
• 中文關鍵字： Premarin and estrogen; urinary calcium and hydroxyproline; menopause; osteoporosis
• 英文關鍵字： --