- 作者: Harekrushna Panda; Ghazala Zaidi; Prakash C. Supakar
- 作者服務機構: Institute of Life Sciences, Bhubaneswar, India
- 中文摘要: --
- 英文摘要: The genetic constitution and differential gene expressionof an organism play important roles in controlling thespecies-specific rate of aging and the maximum life spanpotential. We utilized a differential-display polymerasechain reaction technique to identify the age-dependentexpression of genes in the rat liver. We demonstrate inthis report, for the first time, that expression of the pan-creatic secretory trypsin inhibitor II(PSTI-II)gene de-clines drastically during aging. We confirmed this de-crease by Northern blot analysis. Low PSTI-II levels inaged animals might result in a lack of protection fromprematurely activated trypsin-like proteases, whichwould thus enhance inflammation.
- 中文關鍵字: --
- 英文關鍵字: --