- 作者: El-Khawass, S.M. ; Farghaly, A.M. ; Chaaban, I. et al.
- 作者服務機構: Dept. of Pharmaceutical Chemistry, Univ. of Alexandria, Alexandria, Egypt
- 中文摘要: A series of novel 4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-ones(III) were synthesized. Thus, the key intermediates, 4-(3-aryl-3-oxopropenyl-1,5-dimethyl-2-phenyl-1H-pyrazol- 3(2H)-ones(II) were cyclized with hydrazine hydrate containing a few drops of ethanol gave the desired pyrazoline derivatives(III), which can be acetylated to afford the target N-acetyl derivatives. On the other hand, the same reaction condition using p-substituted phenylhydrazines, the starting key intermediates(II) were recovered unchanged. The use of glacial acetic acid instead of ethanol, lead to a new series of 1,3-diarylpyrazoles by a different pathway. The structure of the newly synthesized compounds was elucidated by elemental analyses, IR,/sup 1/H-NMR and mass spectra.
- 英文摘要: --
- 中文關鍵字: Antipyrine; 3-Oxopropenyl; Pyrazole; Hydrazine
- 英文關鍵字: 安替比林;3-氧丙烯基;唑;聯氨