- 作者: David E. Mold ; Tzyy-Choou Wu ; Frederic Askin ; Ru Chih C. Huang
- 作者服務機構: a Department of Biology,The Johns Hopkins University, and ; b Department of Pathology, The Johns Hopkins Hospital, Baltimore, Md., USA
- 中文摘要: --
- 英文摘要: The human genome contains abundant copies of HERV-K endogenous retrovirus sequences. These remnants of ancient infection have the potential to reshape the genome by retrotransposition or infection since they are highly expressed in cells of germ line origin. When conserved nucleotide sequence variations in the U3 region of the HERV-K 3' LTR were used to distinguish between individual HERV-K proviruses, 4 major classes of HERV-K LTRs were identified. HERV-K U3 regions from the different classes were compared in an in vitro transcription assay and were found to vary significantly in their promoter activities.
- 中文關鍵字: --
- 英文關鍵字: Human endogenous retrovirus ; LTR U3 DNA sequence ; In vitro transcription