• 作者： 何延光; 李文權
• 作者服務機構： 美國加州舊金山市立學院生物系; 國立中興大學農藝系
• 中文摘要： 將野生品系果蠅（簡稱WT）與黃嘌呤脫氫?含量輕低的突變種果蠅（簡稱LXD），連續在正常培養基及添加腺嘌呤
  (adenine)的培養基內培養六代。分別觀察其存活率及尿酸含量。結果發現，雖然腺嘌呤對兩種果蠅都有毒性。但對LXD
  果蠅之毒性較輕。由尿酸含量可以看出。野生品系果蠅很難經過某種去毒代謝通路將腺嘌呤代謝，以致大量轉變為尿酸
  。同時，兩種品系的雄性果蠅，對腺嘌呤的毒性均較雌性果蠅更為敏感。此結果說明，低黃嘌呤脫氫?品系具有某種酵
  素的分解模式來減輕腺嘌呤的毒性。
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• 英文摘要： Survival rates of two Drosophila melanogaster strains, the Oregon R Wild Type (WT), and a mutantthat was Low Xanthine Dehydrogenase (LXD), grown for six generations in control and in adenine-supple-mented media, were determined. Although adenine was toxic to both strains, it was less toxic to the LXDstrain. Uric acid levels indicated that WT Drosophila melanogaster was less able to metabolize adeninethrough the detoxification pathway. Male flies of both strains appeared to be more susceptible to adeninetoxicity than were female. The results demonstrate that the adenine resistant strain may possess an enzymepattern to minimize the toxic effect of adenine.
• 中文關鍵字： Drosophila melanogaster; Low Xanthine Dehydrogenase; Uric acid; adenine selection
• 英文關鍵字： --