• 作者： 嚴震東; 黃基礎
• 作者服務機構： 臺灣大學動物系; 臺灣師範大學生物系
• 中文摘要： 實驗以電刺激及化學刺激方法來研究延腦縫合核(MRN)對膈神經活性及主動脈血壓的區域性控制。實驗動物為去大腦，迷走神經切除，麻痺但不麻醉的貓。使用恆電流刺激來探測MRN內每一點對呼吸及血壓的影響。發現電刺激MRN吻端的點造成膈神經活性強度減低，頻率增高，血壓升高。而刺激MRN尾端造成膈神經活性強度，頻率及血壓均增高。在電刺激有反應的部位微量注入麩胺酸溶液來興奮神經細胞本體，也發現有相似的呼吸及血壓的反應。因此，我們的結論是MRN尾端神經細胞對心臟血管的節前神經元和膈神經運動神經元有興奮性的聯結，而MRN吻端與此二種運動神經元有興奮性及抑制性的聯結。
• 英文摘要： Electrical and chemical stimulation methods were used to determine the topographic organizationof the medullary raphe nuclei (MRN) in controlling the systemic arterial blood pressure (BP) and phrenicnerve activities (PNA). Decerebrated, unanesthetized and bilateral vagotomized cats were used. Effectivepoints in the MRN were systematically explored with constant current stimulation. We found stimulationof the rostral MRN porduced a decrease in PNA amplitude and increases in BP and PNA frequency. Stimu-lation of the caudal MRN produced increases in BP and the amplitude and frequency of PNA. Microinjectionof glutamate solution into the caudal or the rostral MRN points produced qualitatively similar results.Thus, we concluded that the caudal MRN neurons had excitatory connections whereas the rostral MRNneurons had excitatory and inhibitory connections to the cardiovascular preganglionic neurons and thephrenic nerve motoneurons.
• 中文關鍵字： medullary rephe nuclei; blood pressure; phrenic nerve activity; cat
• 英文關鍵字： --