• 作者： 王朝鐘; 孫璐西; 林仁混
• 作者服務機構： 台大醫學院生化學研究所; 台大農學院食品科技研究所; 中山醫學院生化學科
• 中文摘要： 黃梔色素以50mg／kg體重之劑量，用胃管飼餵大白鼠3天或8天均不會影響老鼠肝功能：以100mg／kg體重之劑量連續14天，則誘發鼠肝之急性損傷；以1%黃梔色素添加於台糖飼料中連續四個月則造成鼠肝之脂肪變性。以50mg／kg體重之劑量用胃管處理8天後會造成鼠肝黑變，但在小於l0mg／kg體重之劑量連續餵食4個月仍不會有肝黑變之現象。鼠肝在黑變後如停止餵食黃梔色素，黑變現象在6天後消失而恢復正常顏色，同時肝受損之現象也漸漸回復。當鼠肝黑變時其24小時排出之尿液中所含紫質之量升高，皮膚亦有紫黑色，且尿液呈黑綠色，此現象類似紫質病。其肝黑變之機轉可能與色素之積聚有關，或是與維生素A過多症有關。由本試驗吾人可以確定在著色劑及調味應用上，黃梔色素之毒性極低，且傷害具可逆性，在人類要攝食能造成鼠肝黑變及肝損害之劑量的機會很小，因此黃梔色素將不致影響人類健康。
• 英文摘要： Crocin dyes, isolated from Gardenia jasminodes, did not affect hepatic function when they wereorally administered to rats in a daily dose of 50mg/kg for 8 days, but could induce acute hepatic discolora-tion. A high dosage of 100 mg/kg for 2 weeks could induce both hepatic damage and black pigmentation,but a lower dose of 100mg/kg for 40 days did not. Rats fed on diet containing 1% of crocin dyes forfour months were shown to have mild hepatic functional disorders and pigmentation. The black pigmenta-tion of the liver and the acute hepatic damage associated with the discoloration were completely reversible.During the period of hepatic pigmentation caused by high dose of crocin dyes, the urine had abnormallyincreased porphyrin excretion and tended to display a blackish green color. The skin also appeared purplishblack. The mechanism of black pigmentation seemed to correlate with the gradual accumulation of crocindyes. In summary, the crocin dyes have a very low toxicity in rats even in high experimental dosage whichwould hardly happen in human practice. It is therefore saggested that the crocin dyes are safe for coloringfoods.
• 中文關鍵字： crocin dyes; hepatic black pigmentation; hepatic function disorder
• 英文關鍵字： --