- 作者: 陳麟慶; 林錦紅; 吳信昇
- 作者服務機構: Graduate Institute of Pharmaceutical Science, Kaohsiung Medical College, Kaohsiung Taiwan 800
- 中文摘要: 5-(3-tert-Butylamino-2-hydroxy) propoxy-3, 4-dihydrocarbostyril (1, carteolol) was prepared by an acid-catalyzed cyclization of the N-pivaloylamino-ester (5), which was obtained by using organolithiation of m-pivaloylanisidine, followed by Witting and catalytic hydrogenation reactions. The total yield of 1 obtained from m-anisidine (2) is 21%.
- 英文摘要: --
- 中文關鍵字: Organolithiation; Adrenergic .beta.-receptor blocking activity.
- 英文關鍵字: Organolithiation; Adrenergic .beta.-receptor blocking activity.