- 作者: Juliann Gong Kiang; George C. Tsokos
- 作者服務機構: Department of Clinical Physiology, Division of Medicine, Walter Reed Army Institute of Research, Washington, D.C., USA
- 中文摘要: --
- 英文摘要: Exposure of cells and organs to heat shock is associated with numerous changes in various cellular metabolic parameters and overexpression of proteins collectively known as heat shock proteins (HSP). In this communication we review the cell-signaling events that are altered in response to heat shock as they relate to the subsequent induction of HSP 70 kd (HSP-70) expression. We also review the mechanisms by which HSP-70 is involved in conferring cyto-protective effects. The possibility of altering HSP expression through manipulations of the cell-signal process has clinical importance.
- 中文關鍵字: --
- 英文關鍵字: Heat shock; Calcium; Sodium; Inositol 1,4,5-trisphosphate ; Heat shock protein 70 kd ; Intracellular pH ; Protection