• 作者： 沈清良; 劉克明
• 作者服務機構： 臺南市國立成功大學醫學院解剖學科; 高雄市立私立高雄醫學院解剖學科
• 中文摘要： 本實驗以電子顯微鏡觀察成年大白鼠單側眼球摘除7至120天後，視神經發生瓦勒安氏變性，其神經膠細胞之反應。反應性星狀膠細胞含有許多濃密小體，大量的微小管，及增殖的神經膠細胞絲。這些星狀膠細胞能輔助性吞噬變性的神經髓鞘，而且形成神經膠瘢痕組織。少突神經膠細胞，藉著溶素體大量的增加，以切斷其被微神經膠細胞與星狀膠細胞吞噬的細胞質延伸突起。微神經膠細胞內含長而且彎曲的顆粒性內質網，非常活躍的高爾基氏複合體、板狀包涵體、以及球狀的脂肪小滴。微神經膠細胞進行吞噬已分解的神經軸突和神經髓鞘，並且加以溶解。
• 英文摘要： The neurological reactions in Wallerian degeneration have been studied by electron microscopy inthe optic nerve of adult albino rats from 7 to 120 days after unilateral enucleation. Reactive astrocytescontained abundant dense bodies, numerous microtubules and hyperplastic glial filaments. These astrocytesalso assisted in phagocytosis of degenerated myelin sheaths and in glial scar formation. Oligodendrocytesdisconnected their cytoplasmic extensions, which were phagocytosed by microglial cells and astrocytes, byincreased production of lysosomes. Microglial cells consisted of crinkled, long, rough endoplasmic reticula,several highly-active Golgi complexes, laminar inclusions and globoid lipid droplets. Microglia engulfed andlysed the disintegrated axons and myelin sheaths.
• 中文關鍵字： neuroglia; adult rat; optic nerve; Wallerian degeneration
• 英文關鍵字： --