- 作者: 楊吉斯 ; 陳宜芬
- 作者服務機構: 中原大學化學系
- 中文摘要: This study presents a Chromatographic Optimization Function (COF) to optimize chromatographic separation conditions. The COF proposed herein provides several advantages over conventional COFs, including the ability to eliminate the ambiguous selection of the weighting factors and easily obtain the acceptable or maximum resolution in the shortest separation time. The parameters used to construct this COF are in the form of sigmoidal functions to reduce the weight of the response for less acceptable conditions and to filter out undesired situations. In addition, resolution between peaks, length of separation time, and number of peaks separated are used as parameters for constructing the proposed COF. Closely examining the performance of the COF for both simulated and experimental chromatographic separations reveals an adequate correlation with human judgment and, also, creates no problems in selecting weighting factors.
- 英文摘要: --
- 中文關鍵字: Chromatography; Multicomponent Separation; Optimization; Simplex Algorithm
- 英文關鍵字: 層析;多成分分離;最適化;單體法