- 作者: 吳天賞
- 作者服務機構: Department of Chemistry, National Cheng Kung University, Tainan, Taiwan 701, R.O.C.
- 中文摘要: Nineteen compounds have been isolated from the methanol extract of the root and aerial parts of Ruta graveolens. The structural elucidation of these isolated compounds were determined by the spectroscopic methods and/or comparison of the physical data with literature values. Their antiplatelet aggregation and cytotoxic activities were examined to find potent antiplatelet aggregation and cytotoxic compounds from natural resources. Among them, dictamine (5), skimmianine (7), psoralen (8), chalepensin (12), clausindin (13), and graveolinine (16) showed significant inhibition of platelet aggregation, induced by arachidonic acid and collagen. Arborinine (2), dictamine (5), isopimpinellin (11), clausindin (13), and graveoline (17) exhibited cytotoxic activity against KB, Hela, DLD, NCI and Hepa tumor cell lines.
- 英文摘要: --
- 中文關鍵字: Ruta graveolens; Rutaceae; Structure elucidation; Antiplatelet aggregation activity; Cytotoxicity.
- 英文關鍵字: Ruta graveolens; Rutaceae; Structure elucidation; Antiplatelet aggregation activity; Cytotoxicity.