- 作者: Seng-Sheen Fan
- 作者服務機構: Department of Biology and Life Science Research Center, Tunghai University, Taichung, Taiwan, ROC
- 中文摘要: --
- 英文摘要: Drosophila eye development is a progressive processincluding cell fate determination, pattern formation, andrhabdomere morphogenesis. During eye development,a dramatic change in cell shape, which involves turningand extension of the photoreceptor apical surface, oc-curs in the early pupal stages. It is known that assemblyand extension of adherens junctions (AJs) play an impor-tant role in this process. In the present study, I show thatmutation of the largest subunit of dynactin complexesencoded by Glued (GI) affects the extension and assem-bly of Ajs in developing photoreceptors. In GI /+ mutantsand transgenic flies expressing the dominant negativeform of Glued, the AJs failed to properly assemble andextend. In addition, the morphogenesis of rhabdomereswas also affected in these flies. Taken together, theseresults suggest that the extension and assembly of AJsas wellas determination of the rhabdomere domain inphotoreceptor development are G/ dependent.
- 中文關鍵字: --
- 英文關鍵字: --