- 作者: 王惠珀 ; 鄭吉元 ; 馬靜然 等
- 作者服務機構: 台灣大學藥學系
- 中文摘要: Dipeptides containing D-phenylglycine or D-p- hydroxyphenylglycine were attached onto the antihypertensive agent .alpha.-methyldopa to form prodrugs. The nonessential amino acids were introduced into the prodrug molecules as tools of chemical delivery to improve the intestinal absorption of the parent drug. Preliminary tests revealed that the prodrugs were stable in phosphate buffer solutions at pH 7.4 (t/sub (1/2)/>10h). These compounds also demonstrated satisfactory stability toward enzymatic degradation in a mucosa preparation isolated from rat intestine, indicating that they might be feasibly formulated as an oral prodrug of .alpha.-methyldopa.
- 英文摘要: --
- 中文關鍵字: Methyldopa; Dipeptide; Antihypertensive Agent; Chemical Delivery
- 英文關鍵字: 甲羥苯丙胺酸;二縮氨酸;抗高血壓藥;化學輸送