- 作者: Zung Fan Yuan, Shu-Chuan, Yang Jenn-Tser Pan
- 作者服務機構: Department of Physiology, National Yang-Ming University, Taipei, Taiwan
- 中文摘要: --
- 英文摘要: Both systemic and central effects of a newly discoveredprolactin (PRL)-releasing factor (PRF), prolactin-releasingpeptide (PrRP), were determined in this study. Systemicinjection of PrRP (1 and 10 g/rat, i.v.) stimulated PRLsecretion in ovariectomized, estrogen-treated rats simi-lar to the effect of another PRF, thyrotropin-releasinghormone (TRH). Pretreatment with a dopamine D2 recep-tor antagonist, sulpiride (1 g/rat, i.v.), potentiated thestimulatory effect of both PrRP and TRH on PRL secre-tion. Using the double-labeling immunohistochemicalmethod, PrRP-immunoreactive terminals were found inclose contact with tyrosine-hydroxylase-immunoreac-tive neurons in the hypothalamic arcuate nucleus. Cen-tral administration of PrRP (0.1-1,000 ng/rat, i.c.v.)stimu-lated tuberoinfundibular but not nigrostriatal dopamin-ergic neuronal activity in 15 min. Levels of 3,4-dihydroxy-phenylacetic acid (DOPAC) in the median eminence andstriatum were used as indices for tuberoinfundibulardopaminergic (TIDA) and nigrostriatal dopaminergicneuronal activities, respectively. The serum PRL level,however, was not significantly changed. Similar treat-ment with TRH (10 ng/rat, i.c.v.) stimulated and inhibitedTIDA neuronal activity and serum PRL, respectively, at30 min. In summary, PrRP may play a role in both thecentral and peripheral control of PRL secretion.
- 中文關鍵字: --
- 英文關鍵字: Prolactin-releasing peptide, Tuberoinfundibular dopaminergic neuron, Prolactin, Thyrotropin-releasing hormone, DOPAC, Striatum