• 作者： 蔡來誠; 羅光瑞; 韓韶華
• 作者服務機構： 榮民總醫院醫學研究部免疫研究室; 榮民總醫院內科部胃腸科
• 中文摘要： 本研究包括B型病毒性慢性活動性肝炎病人39人，及正常人39人作為對照。以薔薇結法測定，T細胞病人組73.1 6.1%對照組69.2 8.7%，抑制性T細胞（T ）病人組11.3 3.1%，對照組9.3 3.O%，輔助性T細胞（T ）病人組33.5 6.7%，正常組34.1 6.3%。兩組分別比較均無顯著差異（P >0.1）。且兩組上述各細胞百分率亦在正常範圍內。以單源抗體測定，T細胞（OKT 3）病人組70.4 9.0%，對照組72.1 6.5%，輔助性T細胞（OKT 4）病人組35.6 9.6%，對照組41.3 7.1%，抑制性T細胞（OKT 8）病人組28.9 7.4%，對照組30.4 5.2%，兩組個別比較亦無顯著差異（P>0.1）。至於其百分率，除一患者之輔助性T細胞略高外（64.0%），其餘均於正常範圍中。有關抑制性T細胞之功能，分別以 Con A激發淋巴細胞變形反應，及以PWM激發正常B細胞產生免疫球蛋白，其抑制力在病人組及對照組中並無顯著差異（P >0.05）。有關輔助性細胞之功能，經二次實驗，發現病人輔助性T細胞促使正常B細胞產生IgG量增加為原來之1.51及1.80倍，比對照組增加為原來之1.13及1.27倍，稍有差異（P <0.05）。至於B細胞產生免疫球蛋白量之研究，兩組結果則無甚差異（P>0.1）。 綜觀上述結果，B型肝炎病毒所引起之慢性肝炎病人，其免疫機轉，除病人輔助性T細胞功能稍有亢進外，其抑制性T細胞功能未見有意義之減損。
• 英文摘要： The study included 39 patients withHBsAg-associated chronic active hepatitis（HB-CAH）and 39 normal subjects for control.By the method of rosette formation, T cellsin the patient group were 73.1 6.1%, inthe control group 69.2 8.7%；T cells inthe patient group 9.3 3.0%, in the controlgroup 11.3 3.1%, T cells in the patientgroup 33.5 6.7%, in the control group 34.1 6.3%. There was no significant difference（P>0.1）between these two groups and thepercentages of their cells were within normallimits. By the method of monoclonal antibo-dies, T cells by OKT3 in patient group were70.4 9.0, in the control group 72.1 6.5%；helper T（T ）cells by OKT4 in thepatient group 35.6 9.6%, in the controlgroup 41.3 7.1%；suppressor T（T ）cellsby OKT8 in the patient group 28.9 7.4%, in the control group 30.4 5.2%0. There wasalso no significant difference（P>0．1）bet-ween these two groups and the percentagesof their cells were also within normal limits，except for one of patient whose T cellswere a little high number (64%). Lymphocytetransformation was stimulated by ConA andthe immunoglobulin production of normal Bcells was stimulated by PWM in order tostudy the function of suppressor T cells. Wefound the suppressive function of T cellsin these two groups was not significantlydifferent (P>0.05). After two experimentson the T function, we found that the patients'T cells could enhance the IgG production ofnormal B cells from original 1.51 folds to1.80 folds. This was a little higher (P<0.05)than that was found in the control group,in which the T cells could enhance the IgGproduction of normal B cells from original1.13 folds to 1.27 folds. However, the amountof immunoglobulins produced by B cells withthe presence of normal T cells in this twogroups were significansly different (P>0.1). From the results of this study, we mayconclud that the function of helper T cellsis slightly enhanced in patients with HBsAg-associated CAH, but the function of suppressorT cells in the patients is not impairedsignificantly.
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