- 作者: Panayotis Pantazis Zhiyong Han Devasis Chatterjee James Wyche
- 作者服務機構: Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, R,I., USA
- 中文摘要: --
- 英文摘要: In addition to being causative agents of infectious dis-eases in animals and humans, DNA viruses have servedas models for the study of eukaryotic molecular mecha-nisms including replication and transcription. Studies ofDNA virus functions utilizing cell-free systems and virus-infected cells in culture, in the presence of the anticancerdrug camptothecin(CPT), have demonstrated that CPTis a potent inhibitor of replication, transcription andpackaging of double-stranded DNA-containing adenovi-ruses, papovaviruses and herpesviruses, and the single-stranded DNA-containing autonomous parvoviruses.CPT inhibits viral functions by inhibiting topoisomer-ase I, a host cell enzyme required for initiation and com-pletion of the viral functions. These findings indicate thatCPT analogues could be developed for use as potentdrugs against DNA viruses.
- 中文關鍵字: --
- 英文關鍵字: Camptothecin. DNA virus. Antiviral agent