- 作者: Chyi-Huey Bai, Jiunn-Rong Chen, Hou-Chang Chiu, Chia-Chi Chou, Lee-Young Chau, Wen-Harn Pan
- 作者服務機構: Central Laboratory, Shin Kong WHS Memorial Hospital, Taipei, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
Background : The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been
shown to be associated with the susceptibility to ischemic event, including coronary
artery disease (CAD), myocardial infarction, and peripheral vascular disease. We
aimed to examine whether the length of (GT)n repeats in HO-1 gene promoter is
associated with ischemic stroke in people with CAD risk factors, especially low level
of HDL.
Methods : A total of 183 consecutive firstever ischemic stroke inpatients and 164 non-stroke
patients were screened for the length of (GT)n repeats in HO-1 promoter. The long (L)
and short (S) genotype are defined as the averaged repeat number>26 and ≦26,
respectively.
Results : Stroke patients tended to have more proportions of hypertension, diabetics and
genotype L, than those of genotype S. Patients with genotype L of HO-1 gene
promoter have higher stroke risk in comparison with genotype S especially in
dyslipidemia individuals. The significant differences on stroke risk in multivariate
odds ratios were found especially in people with low HDL-C levels.
Conclusions : Subjects carrying longer (GT)n repeats in HO-1 gene promoter may have greater
susceptibility to develop cerebral ischemic only in the presence of low HDL-C,
suggesting the protective effects in HO-1 genotype S in the process of ischemic
stroke, particularly in subjects with poor HDL-C status. - 中文關鍵字: --
- 英文關鍵字: --