• 作者： 蔡長添
• 作者服務機構： 國防醫學院藥理系
• 中文摘要： 重量 200 至 300 克的雌性大白鼠為這一研究之實驗動物。動物經麻醉 (Urethane 1.25克/公斤) 固定在立體
  定位儀上，由腦記錄黑質部的細胞外電位，並觀察嗎啡對侵害刺激所引起之黑質細胞的抑制之影響。侵害刺激有：夾擊
  尾部、熱水燙尾、聚光燙尾及皮下注射 EDTA 。結果各種不同的侵害刺激都抑制黑質細胞之活動，靜脈注射嗎啡 (2
  mg/kg) 及皮下注射 Aspirin (500 mg/kg) 消除了這種因侵害刺激對黑質細胞活動所引起的抑制，靜脈注射 Nalox-
  one (0.2 mg/kg) ?消除了嗎啡對此抑制作用之影響。結論是：(1)對黑質細胞活動之抑制是疼痛刺激所引起。(2)嗎啡
  之消除此抑制作用是具有葯理專一性的。
• 英文摘要： Extracellular recordings of the neuronal discharges in substantia nigra pars compacta (SNC) werestudied in urethane anesthetized rats. The effects of morphine on the inhibition of the neuronal activityof SNC neurons evoked by noxious stimuli were investigated. The noxious stimuli were produced by tailpinch (TP) - heating of the tail with hot water (HW) or radiant heat (HT) - and intradermal injection ofEDTA. Spontaneous firings of SNC neurons were inhibited by noxious stimuli; this inhibition of firingrates was blocked by morphine (2 mg/kg, i.v.) and aspirin (500 mg/kg, s.c.). Furthermore, the effect ofmorphine on the inhibition of firing rates was antagonized by naloxone (0.2 mg/kg, i.v). It is concludedthat the noxious stimuli which caused inhibition of SNC neurons are probably painful in nature and themorphine action in prevention of the inhibition has a specific narcotic effect.
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