- 作者: Aleksandra Klemba; Magdalena Kowalewska; Wojciech Kukwa; Katarzyna Tonska; Aleksandra Szybinska; Malgorzata Mossakowska; Anna Scinska; Pawel Golik; Kamil Koper; Jakub Radziszewski; Andrzej Kukwa; Anna M Czarnecka; Ewa Bartnik
- 作者服務機構: Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, ul. Pawinskiego 5A, Warsaw, Poland
- 中文摘要: --
- 英文摘要:
Vulvar squamous cell carcinoma (VSCC) is a rare female genital neoplasm. Although
numerous molecular changes have been reported in VSCC, biomarkers of clinical relevance
are still lacking. On the other hand, there is emerging evidence on the use of mtDNA as a
diagnostic tool in oncology. In order to investigate mtDNA status in VSCC patients,
haplogroup distribution analysis and D-loop sequencing were performed. The results were
compared with available data for the general Polish population, cancer free-centenarians as
well as patients with endometrial and head and neck cancer. The obtained data were also
compared with the current status of mitochondrial databases. Significant differences in
haplogroup distribution between VSCC cohort, general Polish population and cancer-free
centenarians cohort were found. Moreover, a correlation between the VSCC patients
haplogroup and HPV status was observed. Finally, a specific pattern of mtDNA
polymorphisms was found in VSCC. Our results suggest that the mitochondrial genetic
background may influence the risk of VSCC occurrence as well as susceptibility to HPV
infection. - 中文關鍵字: --
- 英文關鍵字: --