- 作者: Cynthia A. Standley; Susan M. Irtenkauf; David B. Cotton
- 作者服務機構: Department of Obstetrics and Gynecology, Wayne State University/Hutzel Hospital, Detroit, Mich., USA
- 中文摘要: --
- 英文摘要: The objective of the present study was to determine whether magnesium sul- fate has anticonvulsant actions in the hippocampal-kindled rat model of epi- lepsy. Fully kindled rats received acute intraperitoneal injections of magne- sium sulfate (270 mg/kg), phenytoin (20 mg/kg) or saline in random order. Electrical seizure duration, behavioral seizure stage and duration of postictal EEG depression were examined 15, 30 and 60 min after injection. In an addi- tional group of rats, kindled seizures were measured before and after chronic (2 h) intraperitoneal injections of magnesium sulfate versus saline. There was a significant decrease in electrical seizure duration (p<0.01) and behavioral seizure stage (p<0.01) with acute magnesium sulfate injections compared to saline injections. Phenytoin had no statistically significant effects on hippo- campal-kindled seizures. Chronic magnesium sulfate treatment significantly reduced behavioral seizure stage at 2, 24, and 48 h postinjection (p < 0.05), but did not affect seizure duration. There was a significant time by treatment effect for magnesium sulfate on postictal EEG depression (p<0.01). We con- dude that in this model of hippocampal epilepsy-induced (kindled) rats, mag- nesium sulfate has significant anticonvulsant effects.
- 中文關鍵字: --
- 英文關鍵字: Seizures; Magnesium; Hippocampus; Kindling