- 作者: Tzer-Min Kuo; Cheng-po Hu; Ya-Ling Chen; Ming-Hsiang Hong; King-Song Jeng; Chun-Chin T Liang; Mong-Liang Chen; Chungming Chang
- 作者服務機構: Division of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
Interleukin-6 (IL-6) is a pleiotropic cytokine with pivotal functions in the regulation of
the biological responses of several target cells including hepatocytes. The level of serum
IL-6 has been reported to be elevated in patients with chronic hepatitis B, cirrhosis and
hepatocellular carcinoma and represents the best marker of HBV-related clinical
progression as compared with several other cytokines. In this study, we found that IL-6
was able to effectively suppress hepatitis B virus (HBV) replication and prevent the
accumulation of HBV covalently closed circular DNA (cccDNA) in a human hepatoma
cell line. We also demonstrated that the suppression of HBV replication by IL-6 requires
concurrently a moderate reduction of viral transcripts/core proteins and a marked
decrease in viral genome-containing nucleocapsids. Studies on the stability of existing
viral capsids suggest that the IL-6 effect on the reduction of genome-containing
nucleocapsids is mediated through the prevention of the formation of genome-containing
nucleocapsids, which is similar to the effect of interferons. However, IFN-α/β and IFN-γ
did not participate in the IL-6-induced suppression of HBV replication. Taken together,
our results will provide important information to better understand the role of IL-6 in the
course of HBV infection. - 中文關鍵字: --
- 英文關鍵字: --