- 作者: Zheng-Hao Tzeng, Shuen-Wen Yang, Pang-Min Liu and Kwun-Min Chen*
- 作者服務機構: Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan 116, R.O.C.
- 中文摘要: Optical resolution of racemic 5-oxo-1-phenyl-pyrazolidine-3-carboxylic acid 2 with L-amino acid methyl ester via the diastereomers formation was investigated. Treatment of racemic 5-oxo-1-phenyl-pyrazolidine-3-carboxylic acid 2 with L-valine methyl ester gave diastereomers with a total yield of 86%. The diastereomeric dipeptides can be easily separated by flash column chromatography. Acidic cleavage of the derived diastereomers gave both the optically pure (+)-(R)- and (-)-(S)-5-oxo-1-phenyl-pyrazolidine-3-carboxylic acid ((+)-(R)-2 and (-)-(S)-2) with a total yield of 94% and 95%, respectively.
- 英文摘要: --
- 中文關鍵字: Optical resolution; Organocatalyst; 5-Oxo-1-phenyl-pyrazolidine-3-carboxylic acid; L-Amino acid.
- 英文關鍵字: --