• 作者： 劉湘梅
• 作者服務機構： 國立成功大學醫學院病理科
• 中文摘要： 近年來的動物實驗中，將矽化合管縫入切斷的神經或肌肉後，發現管中不久產生含有血漿的液體以及纖維蛋白合成的凝塊。此因傷口附近血管滲透性增加，引起血漿外流，組織壓力升高，滲入組織以及矽管內。在早期內血漿所含之神經管營養素及纖維蛋白凝塊共同促進神經軸突及內皮細胞之生長及遷移。稍後，纖維蛋白凝塊發生溶解，而被其時產生的結締纖維所代替，後者對於神經及血管的分化構成扮演重要角色。此類實驗證明纖維蛋白質的凝固及溶解不僅是“血液學”中重要項目，而且還牽連到神經及血管再生以及傷口癒合。以上的新發現及構想表示，我人需要溶合多方面的研究方式及成果，方能了解生物醫學上的一些基本原則。
• 英文摘要： Recent experimental studies using wound chambers (silicone tubes) sutured to the transected ratsciatic nerve or thigh muscle have shown an accumulation of plasma-containing fluid and the formationof a fibrin/fibronectin clot within the chambers during the early phase. The plasma proteins leaked intothe wound due to increased vascular permeability caused ty the trauma. The fibrin/fibronectin clot inconcert with neurotrophic factors play a key role in the promotion of growth and migration coincidedwith removal of fibrin through fibrinolysis and collagen deposition in the extracellular space. The appearanceof extracellular matrix was closely related to the morphological event of differentiatioin and formation ofopen capillaries and nerve fascicles. These findings suggest that in addition to hemostasis, fibrin poly-merization (thrombosis) and fibrinolysis play vital pathophysiological roles in angiogenesis, nerve regenera-tion and other aspects of wound healing. These studies emphasize the importance of integration informationfrom many areas of research in order to understand some of th basic principles in Biology and Medicine.
• 中文關鍵字： wound healing; angiogenesis; nerve regeneration; fibrin; fibrinolysis.
• 英文關鍵字： --