- 作者: Thallampuranam Krishnaswamy Suresh Kumar ; Shunmugiah Thevar Karutha Pandian ; Gurunathan Jayaraman ; Ho-Jen Peng ; Chin Yu
- 中文摘要: Cardiotoxins and neurotoxins derived from cobra venoms are small molecular weight (6.5-9.0 kDa) homologous proteins with a high degree of disulfide crosslinking. The lethality of the cobra venoms are attributed to the cardio- and neurotoxins. The three-dimensional structures of the members of these two classes of toxins show striking resemblance. Both cardio-and neurotoxins are "three-finger" shaped proteins with three loops projecting from a globular head. The secondary structural elements in both of the toxins include an antiparallel triple and a double stranded b-sheet. Interestingly, despite the fact that the overall topologies of their three-dimensional structures are similar, cardio- and neurotoxins show drastically different biological properties. The molecular basis for the differential functional properties of these two classes of toxins is still not clear. The aim of this comprehensive review is to summarize and critically evaluate recent progress in research on the structure, function and folding aspects of cobra venom cardio- and neurotoxins.
- 英文摘要: --
- 中文關鍵字: all b-sheet proteins, cobra toxins, folding, function, structure
- 英文關鍵字: --