- 作者: Yi-Ruu Lin; Hwei-Hsien Chen; Yu-Chin Lin; Chien-Hsin Ko; Ming-Huan Chan
- 作者服務機構: Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
The antinociceptive effects of honokiol and magnolol, two major bioactive constituents of the bark
of Magnolia officinalis, were investigated on animal paw licking responses and thermal hyperalgesia
induced by glutamate receptor agonists including glutamate, N-methyl-D-aspartate (NMDA), and
metabotropic glutamate 5 receptor (mGluR5) activator (RS)-2-chloro-5-hydroxyphenylglycine
(CHPG), as well as inflammatory mediators such as substance P and prostaglandin E2 (PGE2) in
mice. The actions of honokiol and magnolol on glutamate-induced c-Fos expression in the spinal
cord dorsal horn were also examined. Our data showed that honokiol and magnolol blocked
glutamate-, substance P- and PGE2-induced inflammatory pain with similar potency and efficacy.
Consistently, honokiol and magnolol significantly decreased glutamate-induced c-Fos protein
expression in superficial (I-II) laminae of the L4-L5 lumbar dorsal horn. However, honokiol was
more selective than magnolol for inhibition of NMDA-induced licking behavioral and thermal
hyperalgesia. In contrast, magnolol was more potent to block CHPG-mediated thermal
hyperalgesia. These results demonstrate that honokiol and magnolol effectively decreased the
inflammatory pain. Furthermore, their different potency on inhibition of nociception provoked by
NMDA receptor and mGluR5 activation should be considered. - 中文關鍵字: --
- 英文關鍵字: --