- 作者: Yi-Ping Hsueh
- 作者服務機構: Institute of Molecular Biology, Academia S璯ica, 128, Sce. 2, Academia Rd, Taipei, 115, Taiwan, Republic of China
- 中文摘要: --
- 英文摘要: Neurofibromin, encoded by the Neurofibromatosis type I (NF1) gene, has been shown to regulate the Ras and cAMP signaling pathways. The signaling functions of neurofibromin may account for tumor formation in patients with NF1, as well as influencing neuronal function. Learning defects have been documented in NFl mutant mice, and in NFl patients, learning disabilities are common. In this review, the recent studies related to the role of neurofibromin in neuronal morphogenesis will be discussed, which may partly explain why the patients with NFl have learning defects.
- 中文關鍵字: --
- 英文關鍵字: syndecan-2, neurofibromatosis type I, NF1, PKA, Ena/VASP proteins, filopodia, dendritic spine, spinogenesis