• 作者： 鍾次文; 劉安國; 尤之浩
• 作者服務機構： 中原大學醫學工程研究所; 臺北市市立忠孝醫院眼科
• 中文摘要： 本研究對21位type Ⅱ糖尿病患及19位正常人進行血液流變性質、視網膜微血管血流速及氧氣傳送效率(TE)之測量與比較。研究結果顯示糖尿病患組呈現較高的血漿黏度(P<0.05)、血液黏度(P<0.05或更佳)及紅血球內黏度(TK) (P<0.002)，但氧氣傳送效率(P<0.001)及視網膜微血管之血流速(P<0.005)卻較低。進一步分析血比容(HCT)與紅血球內黏度之相關性發現，在同一剪切率下，對兩組被研究者而言，此兩參數皆具負相闡性，如：225 1/sec，病患組(R=-0.63，n=21，P<0.005)、正常組(R=-0.84，n=19，P<0.001)及全組(R=-0.70，n=40，P<0.001)；也就是具有較高紅血球內黏度者，其血液之血比容較低。由上述資料顯示病患組因具有較差之血液流變性質及較高之紅血球內黏度，應是造成視網膜微血管之血流速降低、較低的氧氣傳送效率及血液中血比容下降的重要原因之一。由於較少氧氣傳送到視網膜或其他器官，可能會加速病患之視網膜及其他微循環疾病惡化程度。
• 英文摘要： Rheological properties of blood, retinal capillary blood flow velocity and oxygen transport efficiency(TE) were measured and calculated from 21 type Ⅱ diabetic patients (NIDDM) and 19 normal subjects.The results showed that the diabetes group had increased plasma viscosity and blood viscosities (P<0.05or better) at all tested shear rates. For both shear rates (γ) of 225 sec and 450 sec, the diabetes groupdisplayed increased internal viscosity of red cells (Tk) (P<0.002 and P<0.001, respectively) but lowervalues of TE (P<0.001, both). A lower value of retinal capillary blood flow velocity (P<0.005) was alsonoted. Upon further analysis of possible relations between Hct values and Tk of red cells, it was foundthat Hct values were linearly correlated with Tk for both shear rates of the diabets group (γ=225 sec andγ=450 sec ; R=-0.63 and -0.65, n=21 and 19, respectively, both P<0.005); control group (γ=225sec and γ=450 sec ; R=-0.84 and -0.82, respectively, n=19, both P<0.001) and all subject (γ=225 sec and γ=450 sec ; R=-0.70 and -0.72, n=40 and 38, respectively, both P<0.001). The impairedrheological properties of blood and internal viscosity of red cells may result in both reduced capillary bloodflow velocities and less oxygen transported to tissues. This may possibly contribute to the deteriorationof retinopathy or microangiopathy in diabetic patients.
• 中文關鍵字： blood viscosity; internal viscosity of red cells; retinal capillary blood flow velocity; oxygen transport; type II diabetes.
• 英文關鍵字： --