- 作者: 沈雅敬*,曾國琳,郭曜豪
- 作者服務機構: School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 100, Taiwan, R.O.C.
- 中文摘要:
The sesquiterpene capnellene-8β,10α-diol (1) was isolated from non-polar extract of the soft coral
Capnella sp. Ten acylation products of capnellene-8β,10α-diol were prepared: 10α-hydroxy-8β-O-benzoylcapnellene (2), 10α-hydroxy-8β-O-p-toluoylcapnellene (3), 10α-hydroxy-8β-O-4-chlorobenzoylcapnellene (4), 10α-hydroxy-8β-O-2-furoylcapnellene (5), 10α-hydroxy-8β-O-2-thiophenoylcapnellene (6), 10α-hydroxy-8β-O-4-fluorobenzoylcapnellene (7), 10α-hydroxy-8β-O-4-propylbenzoylcapnellene (8), 10α-hydroxy-8β-O-cinnamoylcapnellene (9), 10α-hydroxy-8β-O-4-nitrobenzoylcapnellene (10), and 10α-hydroxy-8β-O-4-anisoylcapnellene (11). The structures of capnellene-8β,10α-diol as well as its derivatives were established through standard spectroscopic analysis. The in vitro cytotoxic activities of the eleven compounds were evaluated against Hela, KB, Daoy, and WiDr human tumor cell lines. - 英文摘要: --
- 中文關鍵字: Capnella sp.; Capnellene-8β,10-diol; Acyl derivatives; Cytotoxicity.
- 英文關鍵字: --