• 作者： 馮憲文; 朱康初; 王榮博; 許劉信; 林滋; 顧湧; 吳麗華; 陳華安; 孫詩潛
• 中文摘要： 體重100-150; Sprague-Dawley種雌性大白鼠，，先由飲水給予0.05％苯巴比妥鈉，一週後再經由皮下注射四氣化碳，每週二次，每次50-100微升，共六週。於是改換腹腔注射雌素二醇，每週三次，每次每100克體重1微克。開始此荷爾蒙注射後第三週，由腹腔或皮下外加注射黃麴毒素B ，每週一次，每次每100克體重100微克，共注射二至九週。黃麴毒素之注射停止後，就不再注射雌素二醇。所得結果顯示，對於曾經苯巴比妥與四氯化碳先行處理的去卵巢大白鼠，黃麴毒素之引發肝癌和皮下惡性腫瘤的作用，能分別被雌素二醇刺激與抑制。
• 英文摘要： Adult female Sprague-Dawley rats, 4weeks after ovariectomy, were given sodiumphenobarbital in their drinking water at aconcentration of 0.5 g/1 until carbon tetra-chloride injections were discontinued. Oneweek after the barbital administration, therats were injected subcutaneously twice aweek for 6 weeks 0.2 ml of 25％ or 50％,carbon tetrachloride in cotton seed oil.They were then separated into 2 groups.One group of them were injected intrape-ritoneally with 1 μg/100 g body weight ofestradiol-17β in the mixture of ethanol andnormal saline (1:4 by volume) 3 times aweek until aflatoxin injections. were dis-continued. The other group were injectedwith the solvent only. Two weeks afterthe hormone treatment was commenced,the rats were injected intraperitoneally orsubcutaneously with 100 μg/100 g bodyweight of aflatoxin B in the mixture ofN, N-dimethylformamide and 1, 2-propyleneglycol (1:1 by volume) once a week for2-9 weeks. The results obtained indicate that thehormone treatment stimulated aflatoxin-induced malignant changes in the liverbut inhibited those in the subcutaneoustissue of ovariectomized rats treated withphenobarbital and carbon tetrachloride.
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