• 作者： 黃銀河; 蔡世仁; 張林松; 余孟芬; 楊玉芝; 沈楚文
• 作者服務機構： Institute and Department of Anatomy; National Yang-Ming University; Department of Psyciatry; Veterans General Hospital-Taipei and National Yang-Ming University
• 中文摘要： 動物若重覆給予安非他命，會產生行為增強的敏感化現象且持續一段時問，故常以此用做精神症的動物模型。本實驗以此動物模型，使用去氧葡萄糖方法（【 C】dexyglucose method）研究大白鼠腦區葡萄糖代謝率改變情形，並與行為測試作比較。 方法是以大白鼠每日腹腔注射安非他命或等量食鹽水，在給或不給安非他命刺激下測42個腦區葡萄糖代謝率改變情形。同樣處理之另一大組大白鼠則作行為測試。 結果顯示經安非他命刺激後，局部葡萄糖代謝率較未刺激組升高很多。雖然安非他命前處理組有較顯著的重覆行為反應，但與此行為相關之腦區的葡萄糖代謝率增強卻不若若食鹽水前處理組。此不一致的現象將在內文討論。另外經安非他命刺激後，兩種前處理組間的局部葡萄糖代謝率差異處較未經安非他命刺激組間的差異多，顯示在臨床研究精神症之萄萄糖代謝率時，給予刺激物可能得到更多的訊息。
• 英文摘要： Chronic amphetamine (AMPH) treatment may cause behavioral sensitization in animals and can beused as an animal model of psychosis. The aim of the study was to check the behavioral and metabolicresponse in this animal model. In rats pretreated with normal saline (NS) or AMPH, with or without AMPH challenge, the[ C]deoxyglucose method was employed to check the metabolic changes in 42 regions. Behavioral testingwas performed in. rats with the same treatment. The results showed that after challenge with AMPH,glucose utilization was enhanced in most of the regions investigated. However, metabolic enhancement ofthe AMPH-pretreated group was lower in the caudate nucleus when compared with that of the NS-pretreatedgroup though the stereotypy rating was higher in the former. Dissociation between the metabolic enhance-ment and behavioral response was noted. Furthermore, more significant differences between the two pre-treated conditions of glucose utilization were found with challenge than without challenge. Further evalua-tion using procedures which include advanced techniques can be applied in further investigation.
• 中文關鍵字： amphetamine; deoxglucose; locomotion; sensitization; stereotypy.
• 英文關鍵字： --