- 作者: María Martín-Vicente, Salvador Resino & Isidoro Martínez
- 作者服務機構: 1.Centro de Investigación Biomédica en Red en Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain 2.Salvador Resino and Isidoro Martínez contributed equally to this study 3.Unidad de Infección Viral E Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III (Campus Majadahonda), Carretera Majadahonda-Pozuelo, Km 2.2, 28220, Majadahonda, Madrid, Spain
- 中文摘要:
- 英文摘要:
The human respiratory syncytial virus (HRSV) causes severe lower respiratory tract infections in infants and the elderly.
An exuberant inadequate immune response is behind most of the pathology caused by the HRSV. The main targets
of HRSV infection are the epithelial cells of the respiratory tract, where the immune response against the virus begins.
This early innate immune response consists of the expression of hundreds of pro-infammatory and anti-viral genes
that stimulates subsequent innate and adaptive immunity. The early innate response in infected cells is mediated by
intracellular signaling pathways composed of pattern recognition receptors (PRRs), adapters, kinases, and transcrip‑
tions factors. These pathways are tightly regulated by complex networks of post-translational modifcations, including
ubiquitination. Numerous ubiquitinases and deubiquitinases make these modifcations reversible and highly dynamic.
The intricate nature of the signaling pathways and their regulation ofers the opportunity for fne-tuning the innate
immune response against HRSV to control virus replication and immunopathology. - 中文關鍵字:
- 英文關鍵字: Ubiquitination, Innate immunity, Immune Response Regulation, Respiratory Syncytial Virus