• 作者： 柴惠珍；尹士俊；李詩慶
• 作者服務機構： 三軍總醫院醫學研究部; 國防醫學院生化研究所
• 中文摘要： 應用體重100?120克的大白鼠施行總膽管結紮手術，結果導致血清膽紅素及肝?與血清鹼性磷酯?活性的增高。以聚丙烯醯胺膠質電泳分離其同功?時，顯示有一異於正常之快速移動的同功?帶，而對骨骼、小腸與正常肝?特異性鹼性磷酯?同功?無影響。膽管結紮手術同時給予黃麴毒素B1( 3 mg / kg體重），則能減低因膽管結紮所導致鹼性磷酯?變化。如 黃麴毒素B1遲至結紮手術後第四天給予時，對血清鹼性磷脂?活性能再度促其增高，然而?有降低肝?鹼性磷酯?活性 的作用。膽管結紮可能增加黃麴毒素B1之急性毒性。
• 英文摘要： A ligation of the common bile duct was performed on male rats of 100-120 g. This procedure produced increases of serum bilirubin and alkaline phosphatase activity in both the liver and the serum. A rapid moving phosphatase, different from the normal liver-specific isozyme, was observed by polya-crylamide gel electrophoresis. No effect on bone-, intestine- and the normal liver-specific phosphatase isozymes was demonstrated. Aflatoxin B1 administration (3 mg/Kg) at the time of bile duct ligation reduced the effect on the phosphatase caused by the ligation of the bile duct. Treatment of AFB1 on the 4th day after ligation, however, further increased the serum alkaline phosphatase activity, but decreased the liver enzyme activity. The ligation of the bile duct may increase the acute toxicity of aflatoxin.
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