- 作者: 張歡歡,胡秀琴*,范桂芳,許鵬飛
- 作者服務機構: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China
- 中文摘要:
The synthesis of some new S-nucleosides of 5-(4-pyridyl)-4-aryl-4H-1,2,4-triazole-3-thiols (4a-n) is
described. Direct glycosylation of (4a-n) with tetra-O-acetyl-α-D-glucopyranosyl bromide in the presence
of potassium hydroxide followed by deacetylation using dry ammonia in methanol gave the corresponding
3-S-(β-D-glucopyranosyl)-5-(4-pyridyl)-4-aryl-4H-1,2,4-triazoles (6a-n) in good yields. All
the compounds were fully characterized by means of 1HNMR, 13C NMR spectra and elemental analyses.
To assist in the interpretation of the spectroscopic data, the crystal structure of 3-S-(2’,3’,4’,6’-tetra-Oacetyl-
β-D-glucopyranosyl)-5-(4-pyridyl)-4-phenyl-4H-1,2,4-triazole (5a) was determined by X-ray diffraction. - 英文摘要: --
- 中文關鍵字: S-nucleosides; 1,2,4-Triazole; Glycosylation; Crystal structure.
- 英文關鍵字: --