• 作者： 洪儒珍; 曹幼民; G.F. Spaulding
• 作者服務機構： 美國阿拉巴馬大學翰咨維校區機械與太空工程學系; 美國德州克魯格生命科學,生物技術研究所; 美國太空總署詹遜太空中心,生物技術研究組
• 中文摘要： 浸埋於培養液中之人體血球對微重力之效應做了研究。本研究針對在15秒內重力加速度由10 至2go （go = 9.81 m/s）的變化下，人體血球形狀變形做了數字模擬的計算。這研究包括變化中的重力加速度加諸於自由浮動血球，血球懸吊於上面斜板及座落於下面斜板之變形反應。計算結果顯示，當重力加速度由微重力增加到二倍重力時，在自由浮動血球及血球座落於下面斜板情形時，血球由球體狀水平拉長變為橢圓體狀。同時在血球懸掛於上面斜板時，球狀血球則變形為垂直拉長橢圓體狀。使用KC-135拋物軌道自由落體飛機做了在不同重力加速度下之人體血球變形之實驗及觀測。這實驗證明了理論模型計算結果與實驗觀測結果吻合一致。本研究提供了人體曝露於微重力環境下之效應，具有非常重要反應的證據。
• 英文摘要： The effects on human cells (lymphocyte) immersed in a culture liquid under microgravity environmenthas been investigated. The study was based on the numerical simulation of the Morphology of human cellsaffected by the time dependent variation of gravity acceleration ranging from 10 to 2 go (go＝9.81 m/s )in 15s. Both the free floating cells and the cells which came into contact with the upper and lower inclinedwalls imposed by the time-dependent reduced gravity acceleration were considered in this study. The resultsshow that, when the gravity acceleration increased, the cell morphology changed from spherical to horizontallyelongated ellipsoid for both the free floating cells and the stationary cells on the lower inclined wall while thecell morphology varied from spherical to vertically-elongated ellipsoid for the cells hanging on the upper in-clined wall. A test of the deformation of human cells exposed to the variation of gravity levels, carried outin the KC-135 free fall aircraft, show that the results of experimental observations agree exactly with the theoreticalmodel computation described in this paper. These results will be useful for study of the behavior and mor-phology of cells in space.
• 中文關鍵字： gravity effect; human cell shape; lymphocyte deformation; osmotic pressure; surface tension.
• 英文關鍵字： --