• 作者： Shiau, Lie-Ding
• 中文摘要： 抗原和抗體相互結合會形成抗原-抗體複合物,這些複合物的許多生理性質和其大小與分子組成均有著密切的關係。本研究中,我們依據分枝程序的統計理論(the statistical theory of branching processes),推導出一系統化的模擬方法,來模擬免疫系統中含有一種具兩個抗原決定位的抗原和兩種不同的單株抗體所形成複合物的大小分布和分子組成。此模擬方法可將抗原和抗體相互結合時的協同性效果(cooperativity effect)對所形成複合物的大小與組成的影響予以探討。模擬結果顯示協同性效果愈大,愈不利於抗原和抗體間的連合,故會形成較小的複合物。
• 英文摘要： The interaction antigen and antibody results in the formation of antigen-antibody complexes. Many physiological properties of these complexes depend on their size and molecular composition. A systematic approach which incorporates the cooperativity effect is developed in this study on the basis of the statistical theory of branching processes. This approach models the size distribution of the immune system containing antigens with two different epitopes and two different types of monoclonal antibodies. The model equations can be solved to demonstrate the effect of the cooperativity on the size distribution of the resulting antigen-antibody complexes. The results indicate that smaller cooperativity factors give rise to smaller complexes as a result of the greater hindrance in proliferation of antigen-antibody complexes.
• 中文關鍵字： 抗原抗體複合物; 大小分布; 協同性效應; 統計模型
• 英文關鍵字： Antigen-Antibody Complex; Size Distribution; Cooperativity Effect; Statistical Model